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We are surfing the wave of quantum decoherance
Decoherence is a fundamental limit on the accuracy of quantum measurements. It applies to all wave-like systems, whether they be particles or fields. The idea is that small perturbations will cause the system to lose coherence with its environment and 'decohere' into a superposition of states (the so-called 'collapse postulate').
This means that quantum systems can never have complete knowledge of their environment. In other words, the state vector is not an exact representation of reality. There are always degrees of uncertainty in measurement.
This means that the observer has an active role in creating reality. Reality is not objective, but a construction of some observer's viewpoint.
Thus, it is not possible to ever have a complete 'theory of everything', because there will always be an uncertainty due to the observer. This means that any ontological interpretation or explanation for reality must incorporate this factor.
Because it is impossible to know if an objective reality exists, there is no reason why we must adhere to realism.
If there is no objective reality to be explained, then the best explanation for phenomena will be one that takes into account all possible interpretations. This is often referred to a multiple realizability.